CultureOne
阿法拉伐CultureOne是专为一次性生物制药加工而打造的优质分离解决方案。CultureOne凭借成熟的创新技术，可温和处理产品，提高产量，为高密度细胞培养提供无与伦比的分离效率。
高端成熟离心机产品，为一次性生物制药生产而生
- 经验证，产品回收率高达99%
- 可轻松扩展至更大型的阿法拉伐不锈钢离心分离机
- 与基于过滤器的采集方法相比，可减少50%至80%的水、能源和清洁剂用量，仅使用少量塑料
- 大容量，高细胞密度，实现快速细胞采集
- 紧凑设计，快速批次转换
CultureOne分离器帮助您充分利用采集的产品。与其他一次性解决方案相比，CultureOne分离器可实现高达99%的产出率。独特的密闭设计，温和处理，减少细胞裂解，避免起泡，方便下游纯化。Spinsert是我们的专利一次性分离片束技术，易于设置和更换，确保快速批量转换。
分离性能卓越，生成高纯度离心分离液，剩余固体含量极低。这最大限度地减少了二次过滤的需要，大大降低生态足迹。
CultureOne分离器操作简单，既可作为独立设备使用，也可连接到集中系统中。自动化和连通性保证了数据的完整性，符合《联邦法规21章》第11款的规定。
您知道吗？
使用阿法拉伐CultureOne系列离心机，轻松高效扩大一次性生物加工。我们的生物处理仪器和自动化解决方案能够帮助您避免浪费数据和时间。它们还满足生产设施的GMP要求，保证系统验证、数据完整性和产品质量。此外，Alfa Laval的专家可以在GMP生产的调试、验证和资格认证期间为您提供支持。
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CultureOne系列
CultureOne分离器提高产品回收率，让从研发到规模生产的一次性生物制药加工流程更加高效。
了解CultureOne系列的工作原理
您想进一步了解CutureOne吗？观看本短片，了解CultureOne的工作方式。查看分离发生的位置、流体进出设备的流动路径，以及设备与操作人员相比的尺寸和规模。
CultureOne Primo
CultureOne Maxi
* 补料分批哺乳动物细胞培养材料的容量数据。实际加工性能取决于单个材料的特性。
有关CultureOne的一些重要事实
提高各个规模生产的产量
CultureOne分离器平台旨在最大限度地发挥每个细胞培养潜能，提供无与伦比的产量，确保产品质量与极高安全性，最大限度地减少细胞裂解。这个系列保证从研发到大规模生产期间性能一致，实现无缝扩展。
与业界共同研发，满足最具挑战的需求
CultureOne分离器系统由阿法拉伐与领先生物医药制造商合作研发而成。它独特的性能已经大量用户验证，能够满足不断变化的市场需求。
减少一次性加工产生的废物量
使用CultureOne分离机，您可以将一次性生物制药加工所需的水、化学品和塑料耗材减少50%到80%。如此一来，成本更低，可持续性更强。
Services
Are you considering single-use centrifugation?
Why switch to single-use processing?
A single-use separation system secures patient safety by eliminating the risk of cross-contamination between batches. Single-use processing also enables a reduced footprint and increased flexibility, with no need for sterilization: empowering manufacturers to bring new treatments to market faster than ever before.
A better harvest with centrifugal separation
Many single-use harvesting systems cannot efficiently separate high-density cell cultures. The resulting product loss dramatically impacts the productivity and profitability of biopharmaceutical operations. CultureOne overcomes this problem by combining high-efficiency centrifugal separation with secure and convenient single-use processing.
Safety and quality with Spinsert™
CultureOne's performance is based on the Spinsert, a patented single-use disposable bowl and disc stack assembly – fully sterilized and ready for processing. Easy to set up and replace, it ensures fast batch changeover. In order to achieve this, Alfa Laval has integrated proven technology from stainless steel separators:
- Hermetic Design, an Alfa Laval unique design, providing low shear, higher product recovery, and foam free separation
- TopStream™ enables continuous concentrated solid ejection during separation
- UniDisc™ increases disc area for improved separation efficiency.
Proven and published
In October 2020, BioProcess International published a study detailing the performance of CultureOne Primo. Made in collaboration with Genentech, the study shows exceptionally efficient separation, with recovery yield rates of up to 99%. In our webinar, Alfa Laval experts discuss the findings of the study. Watch the video and read the whitepaper to know more.
Test, validate, and scale up your next separation solution
Whether upgrading your production line or running a proof of concept, Alfa Laval helps you choose the right separator solution with confidence. Simply get in touch to arrange a consultation and trial at one of our test centres, or to rent a unit for onsite testing.
Get the answers you need
Visit the Q&A section for answers to some of the most common questions about CultureOne and its potential – or send your question to our experts.